Xing S et al. observed increased PRR15 in colon adenocarcinoma than in normal controls, and discovered that PRR15 is a crucial gene involved in the treatment of colon cancer with irinotecan and the Chinese herbal preparation PHY906 through the induction of cell apoptosis by the generation of reactive oxygen species, and inhibition of bacterial growth and inflammation [9]. Here, PRR15 is linked to colonic neoplasm.