A study investigating the expression of Prr15/PRR15 in gastrointestinal (GI) neoplasia indicated that Prr15/PRR15 is differentially expressed in mouse GI tumors and human colorectal cancer (CRC) caused by different gene mutations, with high Prr15/PRR15 levels in murine GI tumors resulting from mutations in the Apc gene, in conjunction with human CRCs. This evidence concerns the gene PRR15 and digestive system neoplasm.