RIPK3-knockout mice were specially protected from injuries that commonly result in chronic liver diseases (e.g., obstructive cholestasis [32, 112], ethanol-induced liver injury [20]), inflammatory liver diseases (e.g., sepsis [113]), and fatty liver-related liver diseases [23], but not in the situation of acute toxic damage as caused by, e.g., acetaminophen, that may lead to an accumulation of unconjugated bile acids in blood [26, 27] (Supplementary Table S1). This evidence concerns the gene RIPK3 and liver disorder.