To be able to explore the function of RIPK3 in hepatocytes, we selected the human hepatoma HepG2 cell line since they do not express RIPK3 endogenously and are utilized as a representative model of the human liver by various laboratories since they display a high degree of morphological and functional differentiation to generate reproducible results [93]. The gene discussed is RIPK3; the disease is hepatocellular carcinoma.