KRT8 and neoplasm: In parallel, GATA3 expression was significantly reduced in PDOs derived from T3/4 tumors compared to Ta (p-value = 0.0003) and to T2 (p-value = 0.0022), and Ck8 expression was significantly decreased in organoids from T3/4 tumors compared to all tumor stages (Ta: p-value <0.0001, T1: p-value = 0.0440, T2: p-value = 0.0004, Supplementary Fig. 12d).