MBD6 and autism: Individual 12 (F11-II-2) also harbors a de novo frameshift VUS in MBD6 (MIM: 619458, c.2337dup [GenBank: NM_052897.4] [p.Gly780Trpfs∗13]); this gene is suspected to be associated with autism and language delay and could contribute to her phenotype.50