These findings also suggest that quantitative assessment of the M+2+6− subpopulation potentially refines the MYC-BCL2 “double expressor lymphoma” (DEL), a term used to describe DLBCL with overexpression of MYC and BCL2 protein in the absence of underlying genetic rearrangements (7, 41, 42). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.