Separately, we have also shown that the iKIR-ligand genotype has direct and measurable consequences for human health, as it affects the risk of developing type 1 diabetes, the rate of progression to a low CD4+ count in people living with HIV-1, the odds of spontaneous clearance of HCV, and the risk of developing inflammatory disease in the context of HTLV-1 infection. The gene discussed is CD4; the disease is type 1 diabetes mellitus.