A total of 433 DEGs representing known pathways for calcium signaling, PI3K/AKT signaling, RAS signaling, MAPK signaling, PPAR signaling, insulin secretion, and dilated and hypertrophic cardiomyopathy signaling were upregulated in Ob/Ob mice bearing Tet2–/– cells compared with WT recipient mice (Supplemental Figure 1I). This evidence concerns the gene INS and hypertrophic cardiomyopathy.