We observed that all analyzed CHIP genes had a higher mutation rate in patients with a high BMI than in those with a low BMI among all 6 cancer types examined, including bladder cancer (BLCA), colon adenocarcinoma (COAD), cervical squamous cell carcinoma/endocervical adenocarcinoma (CESC), rectum adenocarcinoma (READ), skin cutaneous melanoma (SKCM), and uterine corpus endometrial carcinoma (UCEC). This evidence concerns the gene STUB1 and cutaneous melanoma.