Our data on Dnmt3a and Asxl1 heterozygous HSC/Ps in Ob/Ob recipient mice were also remarkable because normal Dnmt3a+/– or Asxl1+/– mice do not manifest any phenotype and show no signs of overt CH or hematologic malignancy (32, 33). Here, DNMT3A is linked to cyclic hematopoiesis.