Recent studies indicate that common inflammatory disease states, such as obesity, diabetes, infection, smoking, and pulmonary inflammation, may contribute to the development of CHIP-associated pathologies, suggesting that environmental factors probably play a key role in CH emergence in HSC/Ps bearing CHIP-associated mutations; however, the mechanisms have not yet been fully elucidated (7–13). The gene discussed is STUB1; the disease is obesity due to melanocortin 4 receptor deficiency.