These data suggest that, among the enrichment of many pathways (Supplemental Figure 1K), loss of Tet2 in pre-LHSCs/PCs under conditions of obesity induced higher intracellular levels of Ca2+, which was associated with reduced 5-hmC levels and exacerbated CH compared with control HSC/Ps. The gene discussed is TET2; the disease is obesity due to melanocortin 4 receptor deficiency.