Certainly, more investigations are needed in other mouse models, including DBA/2J-mdx mice, and higher vertebrates, such as the golden retriever muscular dystrophy model, to test whether overexpression of TAK1 and TAB1 ameliorates dystrophinopathy and improve muscle mass. The gene discussed is TAB1; the disease is neuromuscular disease caused by qualitative or quantitative defects of dystrophin.