FCN2 and spondylo-ocular syndrome: Because we have previously identified and validated L-ficolin, HA, and ST2 as SOS risk biomarkers, we next conducted measurements of L-ficolin, HA, and ST2 on days 3 and 7 after HCT in a prospective cohort of 80 pediatric patients to evaluate NPV and PPV of these risk biomarkers for SOS occurrence, as recommended in the 2014 NIH Consensus Development Project on biomarkers (20, 21).