IQGAP1 couples HA/CD44 to cytoskeletal functions in other cells: IQGAP1 promotes HA-induced migration and proliferation of fibroblasts (Kozlova et al., 2012) and CD44-mediated adhesion of glioblastoma cells to HA-rich ECM (Wolf et al., 2020). The gene discussed is CD44; the disease is glioblastoma.