EGFR: The EGFR:IQGAP1 complex was identified by mass spectrometry (Blagoev et al., 2003), and later confirmed in A431 epidermoid carcinoma (McNulty et al., 2011), breast carcinoma (Chen et al., 2019), and ovarian cancer cells (Chen et al., 2022). This evidence concerns the gene IQGAP1 and squamous cell carcinoma.