As mentioned earlier, the use of larger VAB could result in a lower FNR, as shown by Tasoulis et al.27, and this technique is already used to omit breast surgery in patients with VAB-confirmed pCR.28 In a multicenter, single-arm trial, breast cancer patients with TN and HER2+ subtype had a minimum of 12 vacuum-assisted 9G core biopsies, after which breast surgery was omitted in 31 patients with a pCR as assessed by these biopsies.28 Median follow-up of 26 months showed no ipsilateral breast cancer recurrences in patients where breast surgery was omitted. Here, ERBB2 is linked to breast carcinoma.