IRF3 and Merkel cell skin cancer: Because domatinostat increased IFN α mRNA and protein expression in MCC cells (Fig. 1b, c), we also determined mRNA expression of interferon-induced genes (ISG) in domatinostat-treated WaGa cells and observed an upregulation of IFNAR1, IFNAR2, JAK2, and IRF3 (Fig. 2d).