GSDME and esophageal squamous cell carcinoma: When ESCC is treated with DHA, certain dying cells show the typical pyroptosis morphologies, such as blowing huge bubbles from the cell membrane, accompanied by reduced expression of pyruvate kinase isoform M2 (PKM2), GSDME, and caspase-3/8 activation, together with GSDME-NT generation [19].