CD8A and neoplasm: In TCGA-derived cases, high-risk patients had increased TIIC levels of activated dendritic cells (aDCs), B cells, CD8+T cells, DCs, macrophages, mast cells, neutrophils, plasmacytoid dendritic cells (pDCs), T-helper cells, Th1-cells, Tfh, Tregs and tumor-infiltrating lymphocytes (TILs) (Figure 7A).