Based on the increase in SREBP-cleavage-activating protein (SCAP)/SREBP-1 expression under low PGRMC1/INSIG-1 expression (18), we previously reported that SREBP-1 increases along with Pgrmc1 KO in liver tissues in NAFLD induced by a high-fat diet (19). The gene discussed is INSIG1; the disease is metabolic dysfunction-associated steatotic liver disease.