Mutations in TP63 are known to cause a number of different malformation syndromes, which include orofacial clefting or limb malformations in their phenotypic presentation, including Ectrodactyly, Ectodermal Dysplasia and Cleft Lip/Palate Syndrome 3 (EEC3), Split Hand/Foot Malformation 4 (SHFM4), Hay–Wells Syndrome, ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) syndrome (including Rapp–Hodgkin syndrome), and Acro‐dermato‐ungual‐lacrimal‐tooth (ADULT) syndrome. This evidence concerns the gene TP63 and split hand-foot malformation.