HLA-DRB1 and orofacial cleft: Although HLA‐DRB5 has not been associated with orofacial clefting or limb malformations, it is one of the HLA‐DRB cluster of genes in the HLA region of chromosome 6 and a paralog of the known oral cleft gene HLA‐DRB1 (Doxiadis et al., 2012), some transcripts of which may overlap.