Model 3: age, sex and number of HbA1c or FG measurements, diabetes duration, BMI, smoking status, physical inactivity, arterial hypertension, number of anti‐hypertensive drugs in use, ambulatory 24 h SBP, presence of micro‐ and macrovascular complications at baseline, serum mean HDL‐ and LDL‐cholesterol, and use of insulin, statins and aspirin, mean fasting glycemia and HbA1c. This evidence concerns the gene INS and diabetes mellitus.