Mechanistically, ASK‐272aa competitively binds Akt1 with ASK1 and antagonizes the Akt1‐induced phosphorylation and inactivation of ASK1, thereby activating ASK1‐induced apoptosis, which in turn leads to reduced gefitinib resistance in lung adenocarcinoma cells.68 This evidence concerns the gene MAP3K5 and lung adenocarcinoma.