circATG4B encodes the protein ATG4B‐222aa, which is a decoy to prevent ATG4B from competitively binding TMED10, thereby allowing an increased amount of ATG4B to be released and accelerating autophagy, ultimately leading to increased autophagy and inducing chemoresistance in colorectal cancer cells72 (Figure 4D). Here, ATG4B is linked to colorectal cancer.