Mechanistically, circPLCE1‐411aa binds to the HSP90α/RPS3 complex and promotes the dissociation of RPS3, an important regulator of NF‐κB, from the complex, leading to ubiquitin‐dependent degradation of RPS3 and ultimately inhibiting NF‐κB signalling, thereby suppressing the proliferation and metastasis of colorectal cancer cells. Here, NFKB1 is linked to colorectal cancer.