AR and neoplasm: Although AR was already cytoplasmic 1 day after castration and the weight of the seminal vesicles was reduced after 3 days in both mouse lines (Fig EV2A–C), histological analyses revealed tumor regression in prostates of Pten/Hif1a(i)pe−/− mice but not in those of Pten(i)pe−/− ones (Fig 2F).