A number of genes encoding cytokines, including Il1b, Cxcl1, and the MDSC‐recruiting factor Cxcl5, were induced by castration (Fig 1H; Dataset EV1), the latter potentially underscoring the enrichment of MDSCs in prostatic tumors of castrated Pten(i)pe−/− mice (Figs 1I and EV1F). Here, CXCL5 is linked to prostate neoplasm.