In this study, we report a connection between LARP1 and O‐GlcNAc transferase (OGT), identify a novel oncogenic circCLNS1A/LARP1/DKK4 cascade, identify that DKK4 is a biomarker for HB diagnosis and prognosis and confirm that LARP1 is a promising therapeutic target. Here, LARP1 is linked to hemoglobin measurement.