FGF21 and Disorder of lipid metabolism: High-fat-diet-fed FGF-21-deficient mice exhibited liver fat accumulation and obvious lipid metabolic disorders; in contrast, injection of FGF-21 protein into diet-induced diabetic mice reversed the steatosis of the liver and restored the normal structure of the liver (Murata, Konishi & Itoh, 2011; Xu et al., 2009).