FOXO1 and neoplasm: The phosphorylated AKT (p-AKT) can activate multiple downstream signaling molecules [12], inhibit tumor cell autophagy through mTOR, phosphorylate MADD, caspase-3, caspase-9, phosphorylate FOXO-1 to control the cell cycle, and promote tumor cell growth and/or metastasis [13,14].