NFKB1 and arthritic joint disease: Evidence suggests that overexpression of TIPE2 reduces the production of proinflammatory cytokine in the development of collagen-induced arthritis by inhibiting the activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB) signaling pathways and alleviates arthritis in mice [12].