A contrary result, however, was confirmed in our study, from which we discovered that the promotion of glycolysis using glucose enhanced the ER stress in BC cells, along with the upregulated levels of CHOP, GRP78, and Caspase-12 (a central caspase implicated in the ER stress-mediated apoptosis [49]), providing another evidence concerning the participation of ER stress in the progression of BC. Here, HSPA5 is linked to breast cancer.