HSPA5 and breast cancer: In other words, in addition to the confirmation suggesting the low expression of TMTC3 in BC, overexpressed TMTC3 abrogated the effects of glucose on promoting the growth of BC cells, along with the downregulation on glucose-induced increased Caspase-12, GRP78, and Bcl-2 expressions yet decreased Bax expression, thus emphasizing both the implication of TMTC3 and the interaction between TMTC3 and glycolysis in BC cells.