In a study by Rivelli et al. in which cinacalcet treatment was followed for three years in 46 patients, it was shown that the calcium level returned to normal and the PTH levels decreased significantly after three years (317 ± 242 vs. 145 ± 72 pg/ml), and it was stated that only one patient had resistant hypercalcemia and was given a parathyroidectomy operation. This evidence concerns the gene PTH and Hypercalcemia.