Given the role of obesity in the pathogenesis of EC and effects of estrogen and hyperinsulinemia on the PI3K/AKT/mTOR pathway3, we explored the effects of olaparib and ONC206 treatment on obese versus lean mice using our Lkb1fl/flp53fl/fl model. This evidence concerns the gene MTOR and obesity due to melanocortin 4 receptor deficiency.