The test panel identified 57 pathogenic or likely pathogenic variants in 9 genes (BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM, APOB, and LDLR) associated with CDC Tier-1 priority syndromes for genetic disease prevention (Hereditary breast and ovarian cancer (HBOC), Lynch syndrome, Familial hypercholesterolemia (FH)) [20] giving a yield of 2.0% for these genes. This evidence concerns the gene MSH2 and hereditary disease.