In the EMPOWER-Lung 1 trial, which included patients with a PD-L1 tumor proportion score (TPS) ≥ 50%, first-line therapy with cemiplimab significantly prolonged the median PFS (8.2 vs. 5.0 months) and OS (21.9 vs. 13.0 months) [138]. The gene discussed is CD274; the disease is neoplasm.