Although the effects of Bor on the autophagy markers appeared to be cell line-dependent, the concurrent changes of LC3-II, SQSTM-1/p62 and beclin-1 levels we observed in Bor-treated cells indicate that Bor interferes with the autophagic activity of human MM cell lines and decreases autophagy in the mouse MM cell line. Here, BECN1 is linked to Miyoshi myopathy.