TGFB1 and glomerulosclerosis: In this sense, although TGF-β1 has anti-inflammatory and immunosuppressive effects, it is overproduced in many pathological conditions that include pulmonary fibrosis, glomerulosclerosis, renal interstitial fibrosis, cirrhosis, Crohn’s disease, cardiomyopathy, scleroderma, and chronic graft-vs-host disease [32].