As the results showed, DCLK1 knockout resulted in a significant inhibitory effect on tumor growth in immunocompetent BALB/c mice (Fig. 3b), while in immunocompromised BALB/c nude mice, the difference between DCLK1-knockout tumors and the control group was not significant (Fig. 3c). The gene discussed is DCLK1; the disease is neoplasm.