Nakanishi and his colleagues pointed out that DCLK1 was specially expressed on intestinal CSCs rather than normal stem cells, which made DCLK1 a promising target for CSCs suppression [15], and the initiating role of DCLK1 in tumorigenesis was subsequently identified in pancreatic cancer (PC) [10]. The gene discussed is DCLK1; the disease is pachyonychia congenita.