Given that the primary driver of NAFLD is the expansion of adipose depots as well as the accumulation of ectopic fat [3], NAFLD may promote the remodeling of the fat distribution [41] and disturb the lipid metabolism, particularly in phospholipids (e.g., LPC, SM, and Cer) and glycerolipids (e.g., diacylglyceride and TG) [10–17]. Here, CBLN1 is linked to metabolic dysfunction-associated steatotic liver disease.