ZG Wu et al. identified 25 m6A-meidated lncRNAs that displayed different expression between osteosarcoma tissues and normal tissues, among which the expression levels of ZBTB32 and DEPTOR were downregulated in osteosarcoma tissues and SPAG4 was the opposite, which might be potential remodeling indicators in the tumor microenvironment and prognostic markers in osteosarcoma [186]. This evidence concerns the gene SPAG4 and osteosarcoma.