Upregulated TRERNA1 then interacted with EZH2, a core subunit of PRC2, and upregulated its expression, which further catalyzed the trimethylation of H3K27me3 to epigenetically silenced the expression of the cyclin-dependent kinases inhibitor p21, leading to enhanced cell proliferation of DLBCL cells [177]. The gene discussed is TRERNA1; the disease is diffuse large B-cell lymphoma.