This RP11/hnRNPA2B1/mRNA complex significantly induced the mRNA degradation of two E3 ligases, siah E3 ubiquitin protein ligase 1 (Siah1) and F-box protein 45 (Fbxo45), which further inhibited the degradation of zinc finger E-box binding homeobox 1 (Zeb1), leading to enhanced CRC metastasis. Here, HNRNPA2B1 is linked to colorectal carcinoma.