During the biosynthesis of THAP7-AS1, Sp1 transcription factor (SP1) bound directly to the THAP7-AS1 promoter region to activate its transcription, and m6A methylation mediated by m6A writer METTL3 induced THAP7-AS1 expression via a IGF2BP1-dependent way, which donates in the metastasis of gastric cancer [113]. Here, SP1 is linked to gastric cancer.