Upregulated FOXD2-AS1 then mediated transcriptional regulation on p21 by recruiting a transcriptional silence factor lysine-specific demethylase 1 (LSD1) to p21 promoter and inhibited its transcription, which relieved the tumor suppression mediated by p21, leading to expedited cervical cancer progression. The gene discussed is CDKN1A; the disease is cervical carcinoma.