The expression of VEGFR-3 in the SLN of tumor metastases showed a tubular pattern, which was consistent with the course of new lymphatic vessels, indicating that TMVP1-ICG-NPs targeting VEGFR-3 could efficiently image metastatic sentinal lymph nodes, also the specific expression of VEGFR-3 on new lymphatic vessels could provide higher specificity than other tumor metastasis targeting peptide [83, 84]. This evidence concerns the gene FLT4 and neoplasm.