TNFRSF11B and cancer: One further study in a general population-based cohort evaluated pre-diagnosis circulating OPG and overall cancer-related mortality (i.e., death from any cancer) [23] and showed that higher OPG concentrations were associated with a higher risk of cancer-related mortality (per 1-standard deviation increase in OPG, HR = 1.25 (1.11–1.39)).