PRRT2 and neuropathy: In addition, we demonstrated an increase in phosphorylated extracellular signal regulated kinase 1/2 (ERK1/2) level with activation of PKC in the fourth to sixth lumbar spinal cord in a mouse model of L-OHP-induced peripheral neuropathy; moreover, we reported the inhibitory effects of PKC inhibitors and mitogen activated protein kinase kinase (MEK) inhibitors on L-OHP-induced neuropathy [18].