In univariate Cox proportional hazards regression analysis, tumor size, positive lymph nodes, positive expression of SDC1 in tumor cells, and negative expression of SDC1 in CAF were significantly associated with distant recurrence and in multivariate Cox proportional hazards regression analysis, positive lymph nodes, negative expression of SDC1 in CAF were significantly associated with distant recurrence (Table 4). This evidence concerns the gene SDC1 and neoplasm.