Genes associated with ER stress (e.g., ATF4, NUPR1, DDIT3, TRIB3, CHAC1, SESN2, HERPUD1) were upregulated and genes related to cardiomyopathy and sarcomeric structure (e.g., MYH7, SYNPO2L, LDB3, ACTN2, MYLK3) were downregulated by afatinib, sorafenib, or high-dose ponatinib. The gene discussed is ACTN2; the disease is cardiomyopathy.