Genes associated with ER stress (e.g., ATF4, NUPR1, DDIT3, TRIB3, CHAC1, SESN2, HERPUD1) were upregulated and genes related to cardiomyopathy and sarcomeric structure (e.g., MYH7, SYNPO2L, LDB3, ACTN2, MYLK3) were downregulated by afatinib, sorafenib, or high-dose ponatinib. Here, SYNPO2L is linked to cardiomyopathy.