LAMC1 and dementia: Using WES data and exome content of WGS data in 19,010 participants from UKB and the Brain Imaging, cognition, dementia, and next-generation genomics (BRIDGET) consortium (Methods and Supplementary Table 1), of whom 4,531, 4,424 and 4,497 had extensive PVS in WM, BG and hippocampus, we identified 19 variants in the chr1q25.3 locus associated with HIP-PVS, including two missense variants (rs20563 and rs20558) and one splice donor insertion (rs34133998) in LAMC1 at P < 5 × 10−8, in strong LD with the GWAS sentinel variant (Supplementary Table 15a).