At chr2q33.2, also associated with WMH, SVS, Alzheimer’s disease and caudate volume5,23,46,47, BG-PVS was associated with higher expression of ICA1L in brain tissues and of NBEAL1 in vascular tissues, similar to TWAS of WMH and SVS5,22. The gene discussed is NBEAL1; the disease is Alzheimer disease.