We next used lineage-specific antibodies to purify SCD patient donor mononuclear cells (CD45+, ‘total bone marrow’), erythroblasts (CD235a+), HSPCs (CD34+), myeloid cells (CD33+) and B cells (CD19+) (Supplementary Table 8 and Extended Data Fig. 2a) and quantified the frequency of HBBS reversion across all lineages for each of the four donors. This evidence concerns the gene CD33 and Schnyder corneal dystrophy.