PTPRC and Schnyder corneal dystrophy: We next used lineage-specific antibodies to purify SCD patient donor mononuclear cells (CD45+, ‘total bone marrow’), erythroblasts (CD235a+), HSPCs (CD34+), myeloid cells (CD33+) and B cells (CD19+) (Supplementary Table 8 and Extended Data Fig. 2a) and quantified the frequency of HBBS reversion across all lineages for each of the four donors.