Based on the defined IRS categories, 72.1% (31/43) of the non-pCR specimens were classifed as showing high expression of IKKα (IRS ≥ 6), while underexpression of IKKα level (IRS ≤ 4) was detected in 69.8% (30/43) of the cancers before neoadjuvant chemotherapy. The gene discussed is CHUK; the disease is cancer.