In order to confirm in vivo that inhibiting IKKα can restore the sensitivity of adriamycin resistant cells to adriamycin, we established transplanted tumor models of MDA-MB-231/ADR cells and MDA-MB-231/ADR cells with IKKα knockdown expression in mice, respectively, to observe the tumor inhibition after adriamycin treatment. The gene discussed is CHUK; the disease is neoplasm.