Next, GSEA was performed and the results showed that the KEGG “Glioma”, “Long term potentiation”, and “JAK-STAT signaling pathway”, and the Hallmark “KRAS signaling up”, “UV response up” and “Myogenesis” were the most enriched in high HhS patients (Fig. 4G, H). This evidence concerns the gene KRAS and central nervous system cancer.