Next, GSEA was performed and the results showed that the KEGG “Glioma”, “Long term potentiation”, and “JAK-STAT signaling pathway”, and the Hallmark “KRAS signaling up”, “UV response up” and “Myogenesis” were the most enriched in high HhS patients (Fig. 4G, H). Here, SOAT1 is linked to central nervous system cancer.