VHL and cancer: The contribution of VHL loss to metastasis is unknown, as there is no correlation between VHL status and clinical outcome.25 We and others have reported that silencing the VHL gene consistently results in epithelial-to-mesenchymal transition (EMT).26–28 EMT is an embryonic program reminiscent of the process that carcinomas adopt during metastatic spread,29 although the direct role of EMT in cancer metastasis is debated.30,31