Since we detected equivalent EZH2 mRNA levels in control and DCAF1-depleted SW620 and Caco2 cells (Fig. 1d and Supplementary Fig. 1b), these results indicate a role for DCAF1 in mediating the stabilization and accumulation of EZH2 protein in colon cancer cells. The gene discussed is DCAF1; the disease is malignant colon neoplasm.