Furthermore, if EZH2T367D phospho-mimicking mutant is expressed in EZH2-depleted cells, target genes were expressed at significantly lower levels, even lower than in control cells—underscoring the importance of DCAF1-EZH2T367p for target gene inactivation in colon cancer cells (Fig. 4e and Supplementary Fig. 11b). Here, DCAF1 is linked to colonic neoplasm.