Ectopic expression of DCAF1 wild type, but not DCAF1K194R kinase-dead mutant, in DCAF1-depleted cells restored the level of EZH2T367p to ~80% of that observed in mock-depleted control cells, a finding in line with the notion that DCAF1 is essential for EZH2T367p process in colon cancer cells (Fig. 2d). Here, DCAF1 is linked to colonic neoplasm.