For the purpose of further validating the positive impact of DCAF1-mediated EZH2T367p on EZH2 stability and function, we expressed EZH2 mutants that harbor alanine substitution (T367A) to block or aspartic acid substitution (T367D) to mimic T367 phosphorylation in EZH2-depleted SW620 colon cancer cells. This evidence concerns the gene EZH2 and malignant colon neoplasm.