However, the inability of CHX to decrease EZH2 protein levels in EZH2T367D-transfected, EZH2-depleted SW620 cells supported the view that DCAF1-mediated T367p is sufficient to generate the higher stability of EZH2 in colon cancer cells (Fig. 3b, right panel). Here, EZH2 is linked to malignant colon neoplasm.