Still, even in the high MOI NS1stop infections, the enhancement in the interferon response associated with defective viral particles was relatively small, increasing the percentage of IFNL1-positive cells from ∼45% to ∼55%—similar to the relatively small, non-significant, difference we measured in our single-cell dataset (Figs 3C and 4B). The gene discussed is IFNL1; the disease is infection.