IFNG and neoplasm: Antibody-mediated bridging between FcγRIIIA/FcγRIIA on NK cells/phagocytes and target antigen on the tumor cells can trigger the release of IFNγ, TNFα, IL6, and MCP-1 during the ADCC reaction (42) and NK cell–secreted IFNγ and TNFα were shown to potentiate the NK-mediated target cell lysis (43).