CD4 and chronic asthma: Pharmacological and genetic abrogation of P2X7R activity was associated with amelioration of acute and chronic asthma; the observation that P2X7R-deficient DC had a reduced capacity to induce the Th2 polarization and the upregulation of P2X7R in macrophages from bronchoalveolar fluid in patients with chronic asthma suggest P2X7R activity could condition the pro-asthmatic response of CD4 T cells in the pathogenesis of this respiratory condition [72].