HAX1 (an anti-apoptotic protein) overexpression induces chemoresistance in BC [131–133], whereas, miR-100 overexpression enhances responsiveness of MDA-MB-231/R and MCF-7/R cells to cisplatin treatment, while promoting cisplatin-driven mitochondrial apoptosis by regulating HAX1 [134]. Here, HAX1 is linked to breast cancer.