TF and hemochromatosis type 1: Genetic testing for HFE p.Cys282Tyr and p.His63Asp should be offered to all individuals of European descent found to have both raised serum ferritin and transferrin saturation, individuals with an isolated raised serum ferritin where no other cause is apparent [111], as well as first-degree relatives of individuals with HFE-related hemochromatosis (see Question 2).