HIF1A and pachyonychia congenita: Gene expression of HIF1α was significantly reduced in all three PC cell lines (in 22Rv1 cell line 3.3-fold compared to control cell line, p < 0.001; in DU145 cell line 4.76-fold compared to control cell line, p < 0.001; in PC3 cell line 7.14-fold compared to control cell line, p < 0.001).