LRRK2 and Parkinson disease: Several Parkinson’s disease causative mutations have been found in proteins functioning in synaptic vesicle endocytosis (e.g., SYNJ1, DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6), SNCA (synuclein alpha) and LRRK2 (leucine rich repeat kinase 2)).